Development of novel fluorescent histamine H(1)-receptor antagonists to study ligand-binding kinetics in living cells

The histamine H(1)-receptor (H(1)R) is an important mediator of allergy and inflammation. H(1)R antagonists have particular clinical utility in allergic rhinitis and urticaria. Here we have developed six novel fluorescent probes for this receptor that are very effective for high resolution confocal...

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Publicado no:Sci Rep
Main Authors: Stoddart, Leigh A., Vernall, Andrea J., Bouzo-Lorenzo, Monica, Bosma, Reggie, Kooistra, Albert J., de Graaf, Chris, Vischer, Henry F., Leurs, Rob, Briddon, Stephen J., Kellam, Barrie, Hill, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5785503/
https://ncbi.nlm.nih.gov/pubmed/29371669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-19714-2
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