Fragment Screening at Adenosine-A(3) Receptors in Living Cells Using a Fluorescence-Based Binding Assay

G protein-coupled receptors (GPCRs) comprise the largest family of transmembrane proteins. For GPCR drug discovery, it is important that ligand affinity is determined in the correct cellular environment and preferably using an unmodified receptor. We developed a live cell high-content screening assa...

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Detaylı Bibliyografya
Asıl Yazarlar: Stoddart, Leigh A., Vernall, Andrea J., Denman, Jessica L., Briddon, Stephen J., Kellam, Barrie, Hill, Stephen J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Elsevier 2012
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3456874/
https://ncbi.nlm.nih.gov/pubmed/22999879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2012.07.014
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