A live cell NanoBRET binding assay allows the study of ligand-binding kinetics to the adenosine A(3) receptor

There is a growing interest in understanding the binding kinetics of compounds that bind to G protein-coupled receptors prior to progressing a lead compound into clinical trials. The widely expressed adenosine A(3) receptor (A(3)AR) has been implicated in a range of diseases including immune conditi...

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Bibliografske podrobnosti
izdano v:Purinergic Signal
Main Authors: Bouzo-Lorenzo, Monica, Stoddart, Leigh A., Xia, Lizi, IJzerman, Adriaan P., Heitman, Laura H., Briddon, Stephen J., Hill, Stephen J.
Format: Artigo
Jezik:Inglês
Izdano: Springer Netherlands 2019
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6635573/
https://ncbi.nlm.nih.gov/pubmed/30919204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11302-019-09650-9
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