Exploring the Effect of Cyclization of Histamine H(1) Receptor Antagonists on Ligand Binding Kinetics

[Image: see text] There is an increasing interest in guiding hit optimization by considering the target binding kinetics of ligands. However, compared to conventional structure–activity relationships, structure–kinetics relationships have not been as thoroughly explored, even for well-studied archet...

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Bibliografiset tiedot
Julkaisussa:ACS Omega
Päätekijät: Wang, Zhiyong, Bosma, Reggie, Kuhne, Sebastiaan, van den Bor, Jelle, Garabitian, Wrej, Vischer, Henry F., Wijtmans, Maikel, Leurs, Rob, de Esch, Iwan J.P.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Chemical Society 2021
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8154229/
https://ncbi.nlm.nih.gov/pubmed/34056427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.0c06358
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