Exploring the Effect of Cyclization of Histamine H(1) Receptor Antagonists on Ligand Binding Kinetics

[Image: see text] There is an increasing interest in guiding hit optimization by considering the target binding kinetics of ligands. However, compared to conventional structure–activity relationships, structure–kinetics relationships have not been as thoroughly explored, even for well-studied archet...

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Publicat a:ACS Omega
Autors principals: Wang, Zhiyong, Bosma, Reggie, Kuhne, Sebastiaan, van den Bor, Jelle, Garabitian, Wrej, Vischer, Henry F., Wijtmans, Maikel, Leurs, Rob, de Esch, Iwan J.P.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2021
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8154229/
https://ncbi.nlm.nih.gov/pubmed/34056427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.0c06358
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