Covalent Inhibition of the Histamine H(3) Receptor

Covalent binding of G protein-coupled receptors by small molecules is a useful approach for better understanding of the structure and function of these proteins. We designed, synthesized and characterized a series of 6 potential covalent ligands for the histamine H(3) receptor (H(3)R). Starting from...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Wágner, Gábor, Mocking, Tamara A. M., Kooistra, Albert J., Slynko, Inna, Ábrányi-Balogh, Péter, Keserű, György M., Wijtmans, Maikel, Vischer, Henry F., de Esch, Iwan J. P., Leurs, Rob
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6943558/
https://ncbi.nlm.nih.gov/pubmed/31835873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24244541
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