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Bromo-Cyclobutenaminones as New Covalent UDP-N-Acetylglucosamine Enolpyruvyl Transferase (MurA) Inhibitors

Drug discovery programs against the antibacterial target UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) have already resulted in covalent inhibitors having small three- and five-membered heterocyclic rings. In the current study, the reactivity of four-membered rings was carefully modulated t...

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Bibliografiske detaljer
Udgivet i:Pharmaceuticals (Basel)
Main Authors: Hamilton, David J., Ábrányi-Balogh, Péter, Keeley, Aaron, Petri, László, Hrast, Martina, Imre, Tímea, Wijtmans, Maikel, Gobec, Stanislav, de Esch, Iwan J. P., Keserű, György Miklós
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7692735/
https://ncbi.nlm.nih.gov/pubmed/33153141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph13110362
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