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Identification of a novel UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) from Vibrio fischeri that confers high fosfomycin resistance in Escherichia coli

MurA (UDP-N-acetylglucosamine enolpyruvyl transferase) is a key enzyme involved in bacterial cell wall peptidoglycan synthesis and a target for the antimicrobial agent fosfomycin, a structural analog of the MurA substrate phosphoenol pyruvate. In this study, we identified, cloned and sequenced a nov...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Kumar, Sanath, Parvathi, Ammini, Hernandez, Ricardo, Cadle, Kathleen, Varela, Manuel F.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2009
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673340/
https://ncbi.nlm.nih.gov/pubmed/19277606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00203-009-0468-9
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