Structure of MurA (UDP-N-acetylglucosamine enolpyruvyl transferase) from Vibrio fischeri in complex with substrate UDP-N-acetylglucosamine and the drug fosfomycin

The development of new antibiotics is necessitated by the rapid development of resistance to current therapies. UDP-N-acetylglucosamine enolpyruvyl transferase (MurA), which catalyzes the first committed step of bacterial peptidoglycan biosynthesis, is a prime candidate for therapeutic intervention....

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Hlavní autoři: Bensen, D. C., Rodriguez, S., Nix, J., Cunningham, M. L., Tari, L. W.
Médium: Artigo
Jazyk:Inglês
Vydáno: International Union of Crystallography 2012
Témata:
Structural Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3325803/
https://ncbi.nlm.nih.gov/pubmed/22505403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309112006720
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