4-(3-Aminoazetidin-1-yl)pyrimidin-2-amines as High-Affinity Non-imidazole Histamine H(3) Receptor Agonists with in Vivo Central Nervous System Activity

[Image: see text] Despite the high diversity of histamine H(3) receptor (H(3)R) antagonist/inverse agonist structures, partial or full H(3)R agonists have typically been imidazole derivatives. An in-house screening campaign intriguingly afforded the non-imidazole 4-(3-azetidin-1-yl)pyrimidin-2-amine...

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Détails bibliographiques
Publié dans:J Med Chem
Auteurs principaux: Wágner, Gábor, Mocking, Tamara A. M., Arimont, Marta, Provensi, Gustavo, Rani, Barbara, Silva-Marques, Bruna, Latacz, Gniewomir, Da Costa Pereira, Daniel, Karatzidou, Christina, Vischer, Henry F., Wijtmans, Maikel, Kieć-Kononowicz, Katarzyna, de Esch, Iwan J. P., Leurs, Rob
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2019
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6912857/
https://ncbi.nlm.nih.gov/pubmed/31675226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b01462
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