Development of novel fluorescent histamine H(1)-receptor antagonists to study ligand-binding kinetics in living cells

The histamine H(1)-receptor (H(1)R) is an important mediator of allergy and inflammation. H(1)R antagonists have particular clinical utility in allergic rhinitis and urticaria. Here we have developed six novel fluorescent probes for this receptor that are very effective for high resolution confocal...

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Xehetasun bibliografikoak
Argitaratua izan da:Sci Rep
Egile Nagusiak: Stoddart, Leigh A., Vernall, Andrea J., Bouzo-Lorenzo, Monica, Bosma, Reggie, Kooistra, Albert J., de Graaf, Chris, Vischer, Henry F., Leurs, Rob, Briddon, Stephen J., Kellam, Barrie, Hill, Stephen J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2018
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5785503/
https://ncbi.nlm.nih.gov/pubmed/29371669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-19714-2
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