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Development of novel fluorescent histamine H(1)-receptor antagonists to study ligand-binding kinetics in living cells
The histamine H(1)-receptor (H(1)R) is an important mediator of allergy and inflammation. H(1)R antagonists have particular clinical utility in allergic rhinitis and urticaria. Here we have developed six novel fluorescent probes for this receptor that are very effective for high resolution confocal...
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| Publié dans: | Sci Rep |
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| Auteurs principaux: | , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group UK
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5785503/ https://ncbi.nlm.nih.gov/pubmed/29371669 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-19714-2 |
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