5-Deazaflavin derivatives as inhibitors of p53 ubiquitination by HDM2()

Based on previous reports of certain 5-deazaflavin derivatives being capable of activating the tumour suppressor p53 in cancer cells through inhibition of the p53-specific ubiquitin E3 ligase HDM2, we have conducted an structure–activity relationship (SAR) analysis through systematic modification of...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Dickens, Michael P., Roxburgh, Patricia, Hock, Andreas, Mezna, Mokdad, Kellam, Barrie, Vousden, Karen H., Fischer, Peter M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier Science 2013
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898830/
https://ncbi.nlm.nih.gov/pubmed/24113239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.09.038
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky