Laddar...
Ubiquitination and Degradation of Mutant p53
While wild-type p53 is normally a rapidly degraded protein, mutant forms of p53 are stabilized and accumulate to high levels in tumor cells. In this study, we show that mutant and wild-type p53 proteins are ubiquitinated and degraded through overlapping but distinct pathways. While Mdm2 can drive th...
Sparad:
| Huvudupphovsmän: | , |
|---|---|
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
American Society for Microbiology (ASM)
2007
|
| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2169174/ https://ncbi.nlm.nih.gov/pubmed/17908790 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00050-07 |
| Taggar: |
Lägg till en tagg
Inga taggar, Lägg till första taggen!
|