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Ubiquitin ligase TRIM71 suppresses ovarian tumorigenesis by degrading mutant p53
Hotspot p53 mutants augment cancer cell proliferation, metastasis and metabolism through their gain-of-function (GOF). Ovarian cancer sustains the highest frequency of TP53 mutations, but the mechanisms underlying regulation of mutant p53s’ GOF in this type of cancer remain incompletely understood....
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| Publicado no: | Cell Death Dis |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6769007/ https://ncbi.nlm.nih.gov/pubmed/31570706 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1977-3 |
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