Ubiquitin ligase TRIM71 suppresses ovarian tumorigenesis by degrading mutant p53

Hotspot p53 mutants augment cancer cell proliferation, metastasis and metabolism through their gain-of-function (GOF). Ovarian cancer sustains the highest frequency of TP53 mutations, but the mechanisms underlying regulation of mutant p53s’ GOF in this type of cancer remain incompletely understood....

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Bibliographic Details
Published in:Cell Death Dis
Main Authors: Chen, Yajie, Hao, Qian, Wang, Jieqiong, Li, Jiajia, Huang, Canhua, Zhang, Yu, Wu, Xiaohua, Lu, Hua, Zhou, Xiang
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6769007/
https://ncbi.nlm.nih.gov/pubmed/31570706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1977-3
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