E3 ubiquitin ligase TRIM32 negatively regulates tumor suppressor p53 to promote tumorigenesis

Tumor suppressor p53 has a key role in maintaining genomic stability and preventing tumorigenesis through its regulation of cellular stress responses, including apoptosis, cell cycle arrest and senescence. To ensure its proper levels and functions in cells, p53 is tightly regulated mainly through po...

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Hlavní autoři: Liu, Ju, Zhang, C, Wang, X L, Ly, P, Belyi, V, Xu-Monette, Z Y, Young, K H, Hu, W, Feng, Z
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2014
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Original Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4211364/
https://ncbi.nlm.nih.gov/pubmed/25146927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.121
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