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E3 ubiquitin ligase TRIM32 negatively regulates tumor suppressor p53 to promote tumorigenesis

Tumor suppressor p53 has a key role in maintaining genomic stability and preventing tumorigenesis through its regulation of cellular stress responses, including apoptosis, cell cycle arrest and senescence. To ensure its proper levels and functions in cells, p53 is tightly regulated mainly through po...

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Detalhes bibliográficos
Main Authors: Liu, Ju, Zhang, C, Wang, X L, Ly, P, Belyi, V, Xu-Monette, Z Y, Young, K H, Hu, W, Feng, Z
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4211364/
https://ncbi.nlm.nih.gov/pubmed/25146927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.121
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