Oncogenic MAGEA-TRIM28 ubiquitin ligase downregulates autophagy by ubiquitinating and degrading AMPK in cancer

Autophagy is commonly altered in cancer and has a complicated, but important role in regulation of tumor growth. Autophagy is often tumor suppressive in the early stages of cancer development, but contributes to the late stages of tumor growth. Because of this, putative oncogenes that modulate autop...

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Bibliographic Details
Published in:Autophagy
Main Authors: Pineda, Carlos T, Potts, Patrick Ryan
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2015
Subjects:
Autophagic Punctum
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4509443/
https://ncbi.nlm.nih.gov/pubmed/25945414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2015.1034420
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