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5-Deazaflavin derivatives as inhibitors of p53 ubiquitination by HDM2()
Based on previous reports of certain 5-deazaflavin derivatives being capable of activating the tumour suppressor p53 in cancer cells through inhibition of the p53-specific ubiquitin E3 ligase HDM2, we have conducted an structure–activity relationship (SAR) analysis through systematic modification of...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier Science
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3898830/ https://ncbi.nlm.nih.gov/pubmed/24113239 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.09.038 |
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