Synthetic lethal targeting of DNA double strand break repair deficient cells by human apurinic/apyrimidinic endonuclease (APE1) inhibitors

An apurinic/apyrimidinic (AP) site is an obligatory cytotoxic intermediate in DNA Base Excision Repair (BER) that is processed by human AP endonuclease 1 (APE1). APE1 is essential for BER and an emerging drug target in cancer. We have isolated novel small molecule inhibitors of APE1. In the current...

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Main Authors: Sultana, Rebeka, McNeill, Daniel R., Abbotts, Rachel, Mohammed, Mohammed Z., Zdzienicka, Małgorzata Z., Qutob, Haitham, Seedhouse, Claire, Laughton, Charles A., Fischer, Peter M., Patel, Poulam M., Wilson, David M., Madhusudan, Srinivasan
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3742328/
https://ncbi.nlm.nih.gov/pubmed/22377908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.27512
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