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Design, Synthesis, and Structure−Activity Relationship Exploration of 1-Substituted 4-Aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one Analogues as Inhibitors of the Annexin A2−S100A10 Protein Interaction
[Image: see text] S100 proteins are small adaptors that regulate the activity of partner proteins by virtue of direct protein interactions. Here, we describe the first small molecule blockers of the interaction between S100A10 and annexin A2. Molecular docking yielded candidate blockers that were sc...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Chemical Society
2011
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| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3081224/ https://ncbi.nlm.nih.gov/pubmed/21375334 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm101212e |
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