All change: protein conformation and the ubiquitination reaction cascade

Por Riedinger, Christiane, Endicott, Jane A
Publicado em 2009

The CDK9 C-helix Exhibits Conformational Plasticity That May Explain the Selectivity of CAN508

Por Baumli, Sonja, Hole, Alison J., Noble, Martin E. M., Endicott, Jane A.
Publicado em 2012

A new crystal form of Lys48-linked diubiquitin

Por Trempe, Jean-François, Brown, Nicholas R., Noble, Martin E. M., Endicott, Jane A.
Publicado em 2010

An Inhibitor’s-Eye View of the ATP-Binding Site of CDKs in Different Regulatory States

Por Echalier, Aude, Hole, Alison J., Lolli, Graziano, Endicott, Jane A., Noble, Martin E. M.
Publicado em 2014

The CDK9 Tail Determines the Reaction Pathway of Positive Transcription Elongation Factor b

Por Baumli, Sonja, Hole, Alison J., Wang, Lan-Zhen, Noble, Martin E.M., Endicott, Jane A.
Publicado em 2012

CDK1 structures reveal conserved and unique features of the essential cell cycle CDK

Por Brown, Nicholas R., Korolchuk, Svitlana, Martin, Mathew P., Stanley, Will A., Moukhametzianov, Rouslan, Noble, Martin E. M., Endicott, Jane A.
Publicado no Nat Commun (2015)

Mechanism of Lys48-linked polyubiquitin chain recognition by the Mud1 UBA domain

Por Trempe, Jean-François, Brown, Nicholas R, Lowe, Edward D, Gordon, Colin, Campbell, Iain D, Noble, Martin E M, Endicott, Jane A
Publicado em 2005

Structure of Rpn10 and Its Interactions with Polyubiquitin Chains and the Proteasome Subunit Rpn12

Por Riedinger, Christiane, Boehringer, Jonas, Trempe, Jean-Francois, Lowe, Edward D., Brown, Nicholas R., Gehring, Kalle, Noble, Martin E. M., Gordon, Colin, Endicott, Jane A.
Publicado em 2010

Comparative Structural and Functional Studies of 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 Inhibitors Suggest the Basis for Isotype Selectivity

Por Hole, Alison J., Baumli, Sonja, Shao, Hao, Shi, Shenhua, Huang, Shiliang, Pepper, Chris, Fischer, Peter M., Wang, Shudong, Endicott, Jane A., Noble, Martin E.
Publicado em 2012

Structural and functional characterization of Rpn12 identifies residues required for Rpn10 proteasome incorporation

Por Boehringer, Jonas, Riedinger, Christiane, Paraskevopoulos, Konstantinos, Johnson, Eachan O. D., Lowe, Edward D., Khoudian, Christina, Smith, Dominique, Noble, Martin E. M., Gordon, Colin, Endicott, Jane A.
Publicado em 2012

CDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma Cells

Por Bettayeb, Karima, Baunbæk, Dianne, Delehouze, Claire, Loaëc, Nadège, Hole, Alison J., Baumli, Sonja, Endicott, Jane A., Douc-Rasy, Setha, Bénard, Jean, Oumata, Nassima, Galons, Hervé, Meijer, Laurent
Publicado em 2010

Substituted 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidines Are Highly Active CDK9 Inhibitors: Synthesis, X-ray Crystal Structures, Structure–Activity Relationship, and Anticancer Acti...

Por Shao, Hao, Shi, Shenhua, Huang, Shiliang, Hole, Alison J., Abbas, Abdullahi Y., Baumli, Sonja, Liu, Xiangrui, Lam, Frankie, Foley, David W., Fischer, Peter M., Noble, Martin, Endicott, Jane A., Pepper, Chris, Wang, Shudong
Publicado em 2013

Identification and Characterization of an Irreversible Inhibitor of CDK2

Por Anscombe, Elizabeth, Meschini, Elisa, Mora-Vidal, Regina, Martin, Mathew P., Staunton, David, Geitmann, Matthis, Danielson, U. Helena, Stanley, Will A., Wang, Lan Z., Reuillon, Tristan, Golding, Bernard T., Cano, Celine, Newell, David R., Noble, Martin E.M., Wedge, Stephen R., Endicott, Jane A., Griffin, Roger J.
Publicado no Chem Biol (2015)