Mechanism of Lys48-linked polyubiquitin chain recognition by the Mud1 UBA domain

The ubiquitin-pathway associated (UBA) domain is a 40-residue polyubiquitin-binding motif. The Schizosaccharomyces pombe protein Mud1 is an ortholog of the Saccharomyces cerevisiae DNA-damage response protein Ddi1 and binds to K48-linked polyubiquitin through its UBA domain. We have solved the cryst...

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Main Authors: Trempe, Jean-François, Brown, Nicholas R, Lowe, Edward D, Gordon, Colin, Campbell, Iain D, Noble, Martin E M, Endicott, Jane A
Formato: Artigo
Idioma:Inglês
Publicado: 2005
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1224687/
https://ncbi.nlm.nih.gov/pubmed/16138082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600797
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