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An Inhibitor’s-Eye View of the ATP-Binding Site of CDKs in Different Regulatory States
[Image: see text] We have used a chemically diverse panel of kinase inhibitors to assess the chemical similarity of the ATP-binding sites of cyclin-dependent kinase (CDK) subfamily members in a range of activation states. Using this approach, we find that different activation states of a particular...
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Main Authors: | , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Chemical
Society
2014
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Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4068217/ https://ncbi.nlm.nih.gov/pubmed/24669831 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb500135f |
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