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The CDK9 C-helix Exhibits Conformational Plasticity That May Explain the Selectivity of CAN508
[Image: see text] CDK9 is the kinase of positive transcription elongation factor b and facilitates the transition of paused RNA polymerase II to processive transcription elongation. CDK9 is a validated target for the treatment of cancer, cardiac hypertrophy, and human immunodeficiency virus. Here we...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3355656/ https://ncbi.nlm.nih.gov/pubmed/22292676 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb2004516 |
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