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The CDK9 Tail Determines the Reaction Pathway of Positive Transcription Elongation Factor b

CDK9, the kinase of positive transcription elongation factor b (P-TEFb), stimulates transcription elongation by phosphorylating RNA polymerase II and transcription elongation factors. Using kinetic analysis of a human P-TEFb complex consisting of CDK9 and cyclin T, we show that the CDK9 C-terminal t...

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Detalhes bibliográficos
Main Authors: Baumli, Sonja, Hole, Alison J., Wang, Lan-Zhen, Noble, Martin E.M., Endicott, Jane A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3469819/
https://ncbi.nlm.nih.gov/pubmed/22959624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2012.08.011
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