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An Inhibitor’s-Eye View of the ATP-Binding Site of CDKs in Different Regulatory States

[Image: see text] We have used a chemically diverse panel of kinase inhibitors to assess the chemical similarity of the ATP-binding sites of cyclin-dependent kinase (CDK) subfamily members in a range of activation states. Using this approach, we find that different activation states of a particular...

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Detalhes bibliográficos
Main Authors: Echalier, Aude, Hole, Alison J., Lolli, Graziano, Endicott, Jane A., Noble, Martin E. M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068217/
https://ncbi.nlm.nih.gov/pubmed/24669831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb500135f
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