The cyclin-dependent kinase inhibitor dinaciclib interacts with the acetyl-lysine recognition site of bromodomains

Por Martin, Mathew P., Olesen, Sanne H., Georg, Gunda I., Schönbrunn, Ernst
Publicado em 2013

A novel approach to the discovery of small molecule ligands of CDK2

Por Martin, Mathew P., Alam, Riazul, Betzi, Stephane, Ingles, Donna J., Zhu, Jin-Yi, Schönbrunn, Ernst
Publicado em 2012

CDK1 structures reveal conserved and unique features of the essential cell cycle CDK

Por Brown, Nicholas R., Korolchuk, Svitlana, Martin, Mathew P., Stanley, Will A., Moukhametzianov, Rouslan, Noble, Martin E. M., Endicott, Jane A.
Publicado no Nat Commun (2015)

Stability of the Human Hsp90-p50(Cdc37) Chaperone Complex against Nucleotides and Hsp90 Inhibitors, and the Influence of Phosphorylation by Casein Kinase 2

Por Olesen, Sanne H., Ingles, Donna J., Zhu, Jin-Yi, Martin, Mathew P., Betzi, Stephane, Georg, Gunda I., Tash, Joseph S., Schönbrunn, Ernst
Publicado no Molecules (2015)

Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors

Por Ember, Stuart W. J., Zhu, Jin-Yi, Olesen, Sanne H., Martin, Mathew P., Becker, Andreas, Berndt, Norbert, Georg, Gunda I., Schönbrunn, Ernst
Publicado em 2014

RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and anti-tumor activities in breast cancer

Por Patel, Ronil A., Forinash, Kara D., Pireddu, Roberta, Sun, Ying, Sun, Nan, Martin, Mathew P., Schönbrunn, Ernst, Lawrence, Nicholas J., Sebti, Saïd M.
Publicado em 2012

A novel mechanism by which small molecule inhibitors induce the DFG flip in Aurora A

Por Martin, Mathew P., Zhu, Jin-Yi, Lawrence, Harshani R., Pireddu, Roberta, Luo, Yunting, Alam, Riazul, Ozcan, Sevil, Sebti, Said M., Lawrence, Nicholas J., Schönbrunn, Ernst
Publicado no ACS Chem Biol (2012)

Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2)

Por Pireddu, Roberta, Forinash, Kara D., Sun, Nan N., Martin, Mathew P., Sung, Shen-Shu, Alexander, Brian, Zhu, Jin-Yi, Guida, Wayne C., Schönbrunn, Ernst, Sebti, Saïd M., Lawrence, Nicholas J.
Publicado em 2012

Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases

Por Schonbrunn, Ernst, Betzi, Stephane, Alam, Riazul, Martin, Mathew P., Becker, Andreas, Han, Huijong, Francis, Rawle, Chakrasali, Ramappa, Jakkaraj, Sudhakar, Kazi, Aslamuzzaman, Sebti, Said M., Cubitt, Christopher L., Gebhard, Anthony W., Hazlehurst, Lori A., Tash, Joseph S., Georg, Gunda I.
Publicado em 2013

Fragment-Based and Structure-Guided Discovery and Optimization of Rho Kinase Inhibitors

Por Li, Rongshi, Martin, Mathew P., Liu, Yan, Wang, Binglin, Patel, Ronil A., Zhu, Jin-Yi, Sun, Nan, Pireddu, Roberta, Lawrence, Nicholas J., Li, Jiannong, Haura, Eric B., Sung, Shen-Shu, Guida, Wayne C., Schonbrunn, Ernst, Sebti, Said M.
Publicado no J Med Chem (2012)

Identification and Characterization of an Irreversible Inhibitor of CDK2

Por Anscombe, Elizabeth, Meschini, Elisa, Mora-Vidal, Regina, Martin, Mathew P., Staunton, David, Geitmann, Matthis, Danielson, U. Helena, Stanley, Will A., Wang, Lan Z., Reuillon, Tristan, Golding, Bernard T., Cano, Celine, Newell, David R., Noble, Martin E.M., Wedge, Stephen R., Endicott, Jane A., Griffin, Roger J.
Publicado no Chem Biol (2015)