Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases

Cyclin-dependent kinases (CDKs) are serine/threonine protein kinases that act as key regulatory elements in cell cycle progression. We describe the development of highly potent diaminothiazole inhibitors of CDK2 (IC(50) = 0.0009 – 0.0015 µM) from a single hit compound with weak inhibitory activity (...

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Detalhes bibliográficos
Main Authors: Schonbrunn, Ernst, Betzi, Stephane, Alam, Riazul, Martin, Mathew P., Becker, Andreas, Han, Huijong, Francis, Rawle, Chakrasali, Ramappa, Jakkaraj, Sudhakar, Kazi, Aslamuzzaman, Sebti, Said M., Cubitt, Christopher L., Gebhard, Anthony W., Hazlehurst, Lori A., Tash, Joseph S., Georg, Gunda I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3714109/
https://ncbi.nlm.nih.gov/pubmed/23600925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm301234k
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