A novel mechanism by which small molecule inhibitors induce the DFG flip in Aurora A

Most protein kinases share a DFG (Asp-Phe-Gly) motif in the ATP site which can assume two distinct conformations, the active DFG-in and the inactive DFG-out states. Small molecule inhibitors able to induce the DFG-out state have received considerable attention in kinase drug discovery. Using a typic...

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Publicat a:ACS Chem Biol
Autors principals: Martin, Mathew P., Zhu, Jin-Yi, Lawrence, Harshani R., Pireddu, Roberta, Luo, Yunting, Alam, Riazul, Ozcan, Sevil, Sebti, Said M., Lawrence, Nicholas J., Schönbrunn, Ernst
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4429595/
https://ncbi.nlm.nih.gov/pubmed/22248356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb200508b
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