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Structural Characterization of the Aurora Kinase B “DFG-flip” Using Metadynamics
Aurora kinase B (AKB), a Ser/Thr kinase that plays a crucial role in mitosis, is overexpressed in several cancers. Clinical inhibitors targeting AKB bind to the active DFG “in” conformation of the kinase. It would be beneficial, however, to understand if AKB is susceptible to type II kinase inhibito...
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| Publicado no: | AAPS J |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7905835/ https://ncbi.nlm.nih.gov/pubmed/31853739 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-019-0399-6 |
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