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Structural Characterization of the Aurora Kinase B “DFG-flip” Using Metadynamics

Aurora kinase B (AKB), a Ser/Thr kinase that plays a crucial role in mitosis, is overexpressed in several cancers. Clinical inhibitors targeting AKB bind to the active DFG “in” conformation of the kinase. It would be beneficial, however, to understand if AKB is susceptible to type II kinase inhibito...

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Dettagli Bibliografici
Pubblicato in:AAPS J
Autori principali: Lakkaniga, Naga Rajiv, Balasubramaniam, Meenakshisundaram, Zhang, Shuxing, Frett, Brendan, Li, Hong-yu
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7905835/
https://ncbi.nlm.nih.gov/pubmed/31853739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-019-0399-6
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