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Structural Characterization of the Aurora Kinase B “DFG-flip” Using Metadynamics

Aurora kinase B (AKB), a Ser/Thr kinase that plays a crucial role in mitosis, is overexpressed in several cancers. Clinical inhibitors targeting AKB bind to the active DFG “in” conformation of the kinase. It would be beneficial, however, to understand if AKB is susceptible to type II kinase inhibito...

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Bibliografski detalji
Izdano u:AAPS J
Glavni autori: Lakkaniga, Naga Rajiv, Balasubramaniam, Meenakshisundaram, Zhang, Shuxing, Frett, Brendan, Li, Hong-yu
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7905835/
https://ncbi.nlm.nih.gov/pubmed/31853739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-019-0399-6
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