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A novel mechanism by which small molecule inhibitors induce the DFG flip in Aurora A
Most protein kinases share a DFG (Asp-Phe-Gly) motif in the ATP site which can assume two distinct conformations, the active DFG-in and the inactive DFG-out states. Small molecule inhibitors able to induce the DFG-out state have received considerable attention in kinase drug discovery. Using a typic...
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| 出版年: | ACS Chem Biol |
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| 主要な著者: | , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4429595/ https://ncbi.nlm.nih.gov/pubmed/22248356 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb200508b |
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