Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors

[Image: see text] Members of the bromodomain and extra terminal (BET) family of proteins are essential for the recognition of acetylated lysine (KAc) residues in histones and have emerged as promising drug targets in cancer, inflammation, and contraception research. In co-crystallization screening c...

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Bibliografiske detaljer
Main Authors: Ember, Stuart W. J., Zhu, Jin-Yi, Olesen, Sanne H., Martin, Mathew P., Becker, Andreas, Berndt, Norbert, Georg, Gunda I., Schönbrunn, Ernst
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2014
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4032195/
https://ncbi.nlm.nih.gov/pubmed/24568369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb500072z
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