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Bromodomain-Containing Protein BRD4 Is Hyperphosphorylated in Mitosis
The epigenetic reader BRD4 binds acetylated histones and plays a central role in controlling cellular gene transcription and proliferation. Dysregulation of BRD4′s activity has been implicated in the pathogenesis of a wide variety of cancers. While blocking BRD4 interaction with acetylated histones...
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| 發表在: | Cancers (Basel) |
|---|---|
| Main Authors: | , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
MDPI
2020
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7353023/ https://ncbi.nlm.nih.gov/pubmed/32575711 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12061637 |
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