Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2)

Potent ROCK inhibitors of a new class of 1-benzyl-3-(4-pyridylthiazol-2-yl)ureas have been identified. Remarkable differences in activity were observed for ureas bearing a benzylic stereogenic center. Derivatives with hydroxy, methoxy and amino groups at the meta position of the phenyl ring give ris...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Pireddu, Roberta, Forinash, Kara D., Sun, Nan N., Martin, Mathew P., Sung, Shen-Shu, Alexander, Brian, Zhu, Jin-Yi, Guida, Wayne C., Schönbrunn, Ernst, Sebti, Saïd M., Lawrence, Nicholas J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3531244/
https://ncbi.nlm.nih.gov/pubmed/23275831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C2MD00320A
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge