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Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2)
Potent ROCK inhibitors of a new class of 1-benzyl-3-(4-pyridylthiazol-2-yl)ureas have been identified. Remarkable differences in activity were observed for ureas bearing a benzylic stereogenic center. Derivatives with hydroxy, methoxy and amino groups at the meta position of the phenyl ring give ris...
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| Główni autorzy: | , , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2012
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3531244/ https://ncbi.nlm.nih.gov/pubmed/23275831 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C2MD00320A |
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