Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2)

Potent ROCK inhibitors of a new class of 1-benzyl-3-(4-pyridylthiazol-2-yl)ureas have been identified. Remarkable differences in activity were observed for ureas bearing a benzylic stereogenic center. Derivatives with hydroxy, methoxy and amino groups at the meta position of the phenyl ring give ris...

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Detalhes bibliográficos
Principais autores: Pireddu, Roberta, Forinash, Kara D., Sun, Nan N., Martin, Mathew P., Sung, Shen-Shu, Alexander, Brian, Zhu, Jin-Yi, Guida, Wayne C., Schönbrunn, Ernst, Sebti, Saïd M., Lawrence, Nicholas J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3531244/
https://ncbi.nlm.nih.gov/pubmed/23275831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C2MD00320A
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