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Development of new N-Arylbenzamides as STAT3 Dimerization Inhibitors
The O-tosylsalicylamide S3I-201 (10) was used as a starting point for design and synthesis of novel STAT-3 dimerization inhibitors with improved drug-like qualities. The phosphonic acid 12d and salicylic acids 13f, 13g with a shorter amide linker lacking the O-tosyl group had improved STAT-3 inhibit...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3780559/ https://ncbi.nlm.nih.gov/pubmed/24073326 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C3MD20323A |
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