Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity

S3I-201 (NSC 74859) is a chemical probe inhibitor of Stat3 activity, which was identified from the National Cancer Institute chemical libraries by using structure-based virtual screening with a computer model of the Stat3 SH2 domain bound to its Stat3 phosphotyrosine peptide derived from the x-ray c...

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Detalhes bibliográficos
Main Authors: Siddiquee, Khandaker, Zhang, Shumin, Guida, Wayne C., Blaskovich, Michelle A., Greedy, Benjamin, Lawrence, Harshani R., Yip, M. L. Richard, Jove, Richard, McLaughlin, Mark M., Lawrence, Nicholas J., Sebti, Said M., Turkson, James
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1863497/
https://ncbi.nlm.nih.gov/pubmed/17463090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609757104
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