CDK1 structures reveal conserved and unique features of the essential cell cycle CDK

CDK1 is the only essential cell cycle CDK in human cells and is required for successful completion of M-phase. It is the founding member of the CDK family and is conserved across all eukaryotes. Here we report the crystal structures of complexes of CDK1–Cks1 and CDK1–cyclin B–Cks2. These structures...

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Publicat a:Nat Commun
Autors principals: Brown, Nicholas R., Korolchuk, Svitlana, Martin, Mathew P., Stanley, Will A., Moukhametzianov, Rouslan, Noble, Martin E. M., Endicott, Jane A.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4413027/
https://ncbi.nlm.nih.gov/pubmed/25864384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7769
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