A novel Cdk9 inhibitor preferentially targets tumor cells and synergizes with fludarabine

Cdk9 is a key elongation factor for RNA transcription and functions by phosphorylating the C-terminal domain of RNA polymerase II. Here we present direct evidence that cdk9 is important for cancer cell survival and describe the characterization of the potent cdk9 inhibitor CDKI-73 in primary human l...

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Detalhes bibliográficos
Main Authors: Walsby, Elisabeth, Pratt, Guy, Shao, Hao, Abbas, Abdullah Y., Fischer, Peter M., Bradshaw, Tracey D., Brennan, Paul, Fegan, Chris, Wang, Shudong, Pepper, Chris
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2013
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3964214/
https://ncbi.nlm.nih.gov/pubmed/24495868
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