Novel pyrrolobenzodiazepine benzofused hybrid molecules inhibit nuclear factor-κB activity and synergize with bortezomib and ibrutinib in hematologic cancers

Chronic lymphocytic leukemia (CLL) and multiple myeloma are incurable hematologic malignancies that are pathologically linked with aberrant nuclear factor-kappa B (NF-κB) activation. In this study, we identified a group of novel C8-linked benzofused pyrrolo[2,1- c][1,4]benzodiazepine monomeric hybri...

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Detalhes bibliográficos
Publicado no:Haematologica
Main Authors: Lewis, Thomas, Corcoran, David B., Thurston, David E., Giles, Peter J., Ashelford, Kevin, Walsby, Elisabeth J., Fegan, Christopher D., Pepper, Andrea G. S., Rahman, Khondaker Miraz, Pepper, Chris
Formato: Artigo
Idioma:Inglês
Publicado em: Fondazione Ferrata Storti 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8018133/
https://ncbi.nlm.nih.gov/pubmed/32381576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2019.238584
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