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From Anthramycin to Pyrrolobenzodiazepine (PBD)‐Containing Antibody–Drug Conjugates (ADCs)

The pyrrolo[2,1‐c][1,4]benzodiazepines (PBDs) are a family of sequence‐selective DNA minor‐groove binding agents that form a covalent aminal bond between their C11‐position and the C2‐NH(2) groups of guanine bases. The first example of a PBD monomer, the natural product anthramycin, was discovered i...

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Bibliografische gegevens
Gepubliceerd in:Angew Chem Int Ed Engl
Hoofdauteurs: Mantaj, Julia, Jackson, Paul J. M., Rahman, Khondaker M., Thurston, David E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2016
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5215561/
https://ncbi.nlm.nih.gov/pubmed/27862776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201510610
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