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From Anthramycin to Pyrrolobenzodiazepine (PBD)‐Containing Antibody–Drug Conjugates (ADCs)
The pyrrolo[2,1‐c][1,4]benzodiazepines (PBDs) are a family of sequence‐selective DNA minor‐groove binding agents that form a covalent aminal bond between their C11‐position and the C2‐NH(2) groups of guanine bases. The first example of a PBD monomer, the natural product anthramycin, was discovered i...
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| Pubblicato in: | Angew Chem Int Ed Engl |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
John Wiley and Sons Inc.
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5215561/ https://ncbi.nlm.nih.gov/pubmed/27862776 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201510610 |
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