Pre-clinical pharmacology and mechanism of action of SG3199, the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine

Synthetic pyrrolobenzodiazepine (PBD) dimers, where two PBD monomers are linked through their aromatic A-ring phenolic C8-positions via a flexible propyldioxy tether, are highly efficient DNA minor groove cross-linking agents with potent cytotoxicity. PBD dimer SG3199 is the released warhead compone...

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Publicado no:Sci Rep
Main Authors: Hartley, John A., Flynn, Michael J., Bingham, John P., Corbett, Simon, Reinert, Halla, Tiberghien, Arnaud, Masterson, Luke A., Antonow, Dyeison, Adams, Lauren, Chowdhury, Sajidah, Williams, David G., Mao, Shenlan, Harper, Jay, Havenith, Carin E. G., Zammarchi, Francesca, Chivers, Simon, van Berkel, Patrick H., Howard, Philip W.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6041317/
https://ncbi.nlm.nih.gov/pubmed/29992976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-28533-4
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