Design and Synthesis of Tesirine, a Clinical Antibody–Drug Conjugate Pyrrolobenzodiazepine Dimer Payload

[Image: see text] Pyrrolobenzodiazepine dimers are an emerging class of warhead in the field of antibody–drug conjugates (ADCs). Tesirine (SG3249) was designed to combine potent antitumor activity with desirable physicochemical properties such as favorable hydrophobicity and improved conjugation cha...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Tiberghien, Arnaud C., Levy, Jean-Noel, Masterson, Luke A., Patel, Neki V., Adams, Lauren R., Corbett, Simon, Williams, David G., Hartley, John A., Howard, Philip W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2016
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5108040/
https://ncbi.nlm.nih.gov/pubmed/27882195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00062
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