Design and Synthesis of Tesirine, a Clinical Antibody–Drug Conjugate Pyrrolobenzodiazepine Dimer Payload

Por Tiberghien, Arnaud C., Levy, Jean-Noel, Masterson, Luke A., Patel, Neki V., Adams, Lauren R., Corbett, Simon, Williams, David G., Hartley, John A., Howard, Philip W.
Publicado no ACS Med Chem Lett (2016)

Antistaphylococcal activity of DNA-interactive pyrrolobenzodiazepine (PBD) dimers and PBD-biaryl conjugates

Por Rahman, Khondaker M., Rosado, Helena, Moreira, Joao B., Feuerbaum, Eva-Anne, Fox, Keith R., Stecher, Eva, Howard, Philip W., Gregson, Stephen J., James, Colin H., de la Fuente, Maria, Waldron, Denise E., Thurston, David E., Taylor, Peter W.
Publicado em 2012

SG2285, a novel C2-aryl-substituted pyrrolobenzodiazepine dimer pro-drug that cross-links DNA and exerts highly potent antitumor activity

Por Hartley, John A., Hamaguchi, Anzu, Coffils, Marissa, Martin, Christopher R.H., Suggitt, Marie, Chen, Zhizhi, Gregson, Stephen J., Masterson, Luke A., Tiberghien, Arnaud C., Hartley, Janet M., Pepper, Christopher, Lin, Thet Thet, Fegan, Christopher, Thurston, David E., Howard, Philip W.
Publicado em 2010