The role of specific ATP-binding cassette transporters in the acquired resistance to pyrrolobenzodiazepine dimer-containing antibody-drug conjugates

por Corbett, Simon, Huang, Shiran, Zammarchi, Francesca, Howard, Philip W, van Berkel, Patrick H, Hartley, John A
Publicado en Mol Cancer Ther (2020)

Design and Synthesis of Tesirine, a Clinical Antibody–Drug Conjugate Pyrrolobenzodiazepine Dimer Payload

por Tiberghien, Arnaud C., Levy, Jean-Noel, Masterson, Luke A., Patel, Neki V., Adams, Lauren R., Corbett, Simon, Williams, David G., Hartley, John A., Howard, Philip W.
Publicado en ACS Med Chem Lett (2016)

Pyrrolobenzodiazepine Antibody-Drug Conjugates Designed for Stable Thiol Conjugation

por Christie, R. James, Tiberghien, Arnaud C., Du, Qun, Bezabeh, Binyam, Fleming, Ryan, Shannon, Amanda, Mao, Shenlan, Breen, Shannon, Zhang, Jing, Zhong, Haihong, Harper, Jay, Wu, Herren, Howard, Philip W., Gao, Changshou
Publicado en Antibodies (Basel) (2017)

Antistaphylococcal activity of DNA-interactive pyrrolobenzodiazepine (PBD) dimers and PBD-biaryl conjugates

por Rahman, Khondaker M., Rosado, Helena, Moreira, Joao B., Feuerbaum, Eva-Anne, Fox, Keith R., Stecher, Eva, Howard, Philip W., Gregson, Stephen J., James, Colin H., de la Fuente, Maria, Waldron, Denise E., Thurston, David E., Taylor, Peter W.
Publicado 2012

SG2285, a novel C2-aryl-substituted pyrrolobenzodiazepine dimer pro-drug that cross-links DNA and exerts highly potent antitumor activity

por Hartley, John A., Hamaguchi, Anzu, Coffils, Marissa, Martin, Christopher R.H., Suggitt, Marie, Chen, Zhizhi, Gregson, Stephen J., Masterson, Luke A., Tiberghien, Arnaud C., Hartley, Janet M., Pepper, Christopher, Lin, Thet Thet, Fegan, Christopher, Thurston, David E., Howard, Philip W.
Publicado 2010

TR1801‐ADC: a highly potent cMet antibody–drug conjugate with high activity in patient‐derived xenograft models of solid tumors

por Gymnopoulos, Marco, Betancourt, Oscar, Blot, Vincent, Fujita, Ryo, Galvan, Diana, Lieuw, Vincent, Nguyen, Sophie, Snedden, Jeanette, Stewart, Christine, Villicana, Jose, Wojciak, Jon, Wong, Eley, Pardo, Raul, Patel, Neki, D’Hooge, Francois, Vijayakrishnan, Balakumar, Barry, Conor, Hartley, John A., Howard, Philip W., Newman, Roland, Coronella, Julia
Publicado en Mol Oncol (2019)

Pre-clinical pharmacology and mechanism of action of SG3199, the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine

por Hartley, John A., Flynn, Michael J., Bingham, John P., Corbett, Simon, Reinert, Halla, Tiberghien, Arnaud, Masterson, Luke A., Antonow, Dyeison, Adams, Lauren, Chowdhury, Sajidah, Williams, David G., Mao, Shenlan, Harper, Jay, Havenith, Carin E. G., Zammarchi, Francesca, Chivers, Simon, van Berkel, Patrick H., Howard, Philip W.
Publicado en Sci Rep (2018)