Antistaphylococcal activity of DNA-interactive pyrrolobenzodiazepine (PBD) dimers and PBD-biaryl conjugates

OBJECTIVES: Pyrrolobenzodiazepine (PBD) dimers, tethered through inert propyldioxy or pentyldioxy linkers, possess potent bactericidal activity against a range of Gram-positive bacteria by virtue of their capacity to cross-link duplex DNA in sequence-selective fashion. Here we attempt to improve the...

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Detalhes bibliográficos
Main Authors: Rahman, Khondaker M., Rosado, Helena, Moreira, Joao B., Feuerbaum, Eva-Anne, Fox, Keith R., Stecher, Eva, Howard, Philip W., Gregson, Stephen J., James, Colin H., de la Fuente, Maria, Waldron, Denise E., Thurston, David E., Taylor, Peter W.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370821/
https://ncbi.nlm.nih.gov/pubmed/22547662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dks127
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