Straightforward Glycoengineering Approach to Site-Specific Antibody–Pyrrolobenzodiazepine Conjugates

[Image: see text] Antibody–drug conjugates (ADCs) have become a powerful platform to deliver cytotoxic agents selectively to cancer cells. ADCs have traditionally been prepared by stochastic conjugation of a cytotoxic drug using an antibody’s native cysteine or lysine residues. Through strategic sel...

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Veröffentlicht in:ACS Med Chem Lett
Hauptverfasser: Thompson, Pamela, Ezeadi, Ebele, Hutchinson, Ian, Fleming, Ryan, Bezabeh, Binyam, Lin, Jia, Mao, Shenlan, Chen, Cui, Masterson, Luke, Zhong, Haihong, Toader, Dorin, Howard, Philip, Wu, Herren, Gao, Changshou, Dimasi, Nazzareno
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2016
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5108038/
https://ncbi.nlm.nih.gov/pubmed/27882199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.6b00278
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