Design and characterization of homogenous antibody-drug conjugates with a drug-to-antibody ratio of one prepared using an engineered antibody and a dual-maleimide pyrrolobenzodiazepine dimer

Most strategies used to prepare homogeneous site-specific antibody-drug conjugates (ADCs) result in ADCs with a drug-to-antibody ratio (DAR) of two. Here, we report a disulfide re-bridging strategy to prepare homogeneous ADCs with DAR of one using a dual-maleimide pyrrolobenzodiazepine (PBD) dimer (...

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Publicado no:MAbs
Main Authors: White, Jason B., Fleming, Ryan, Masterson, Luke, Ruddle, Ben T., Zhong, Haihong, Fazenbaker, Christine, Strout, Patrick, Rosenthal, Kim, Reed, Molly, Muniz-Medina, Vanessa, Howard, Philip, Dixit, Rakesh, Wu, Herren, Hinrichs, Mary Jane, Gao, Changshou, Dimasi, Nazzareno
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
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Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6512924/
https://ncbi.nlm.nih.gov/pubmed/30835621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2019.1578611
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