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Covalent Bonding of Pyrrolobenzodiazepines (PBDs) to Terminal Guanine Residues within Duplex and Hairpin DNA Fragments
Pyrrolobenzodiazepines (PBDs) are covalent-binding DNA-interactive agents with growing importance as payloads in Antibody Drug Conjugates (ADCs). Until now, PBDs were thought to covalently bond to C2-NH(2) groups of guanines in the DNA-minor groove across a three-base-pair recognition sequence. Usin...
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| Publicado no: | PLoS One |
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| Principais autores: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4824457/ https://ncbi.nlm.nih.gov/pubmed/27055050 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0152303 |
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