Sphingosine 1-phosphate Chemical Biology

ανά Lynch, Kevin R., Macdonald, Timothy L.
Έκδοση 2008

Cost-effective and Large-scale synthesis of 16:0 Lysophosphatidic Acid

ανά East, James E., Macdonald, Timothy L.
Έκδοση 2012

Sphingosine-1-Phosphate Receptor Subtypes Differentially Regulate Smooth Muscle Cell Phenotype

ανά Wamhoff, Brian R., Lynch, Kevin R., Macdonald, Timothy L., Owens, Gary K.
Έκδοση 2008

Cyclic AMP-dependent inhibition of human neutrophil oxidative activity by substituted 2-propynylcyclohexyl adenosine A(2A) receptor agonists

ανά Sullivan, Gail W, Rieger, Jayson M, Michael Scheld, W, Macdonald, Timothy L, Linden, Joel
Έκδοση 2001

The isothiocyanate class of bioactive nutrients covalently inhibit the MEKK1 protein kinase

ανά Cross, Janet V, Foss, Frank W, Rady, Joshua M, Macdonald, Timothy L, Templeton, Dennis J
Έκδοση 2007

α- and β-Substituted phosphonate analogs of LPA as autotaxin inhibitors

ανά Cui, Peng, McCalmont, William F., Tomsig, Jose L., Lynch, Kevin R., Macdonald, Timothy L.
Έκδοση 2007

Biological Activity of Modified and Exchanged 2-Amino-5-Nitrothiazole Amide Analogues of Nitazoxanide

ανά Ballard, T. Eric, Wang, Xia, Olekhnovich, Igor, Koerner, Taylor, Seymour, Craig, Hoffman, Paul S., Macdonald, Timothy L.
Έκδοση 2010

Nitazoxanide Inhibits Biofilm Formation by Staphylococcus epidermidis by Blocking Accumulation on Surfaces

ανά Tchouaffi-Nana, Florence, Ballard, T. Eric, Cary, Christine H., Macdonald, Timothy L., Sifri, Costi D., Hoffman, Paul S.
Έκδοση 2010

Inhibition of autotaxin production or activity blocks lysophosphatidylcholine-induced migration of human breast cancer and melanoma cells

ανά Gaetano, Cristoforo G., Samadi, Nasser, Tomsig, Jose L., Macdonald, Timothy L., Lynch, Kevin R., Brindley, David N.
Έκδοση 2009

Nutrient Isothiocyanates Covalently Modify and Inhibit the Inflammatory Cytokine Macrophage Migration Inhibitory Factor (MIF)

ανά Cross, Janet V., Rady, Joshua M., Foss, Frank W., Lyons, Charles, Macdonald, Timothy L., Templeton, Dennis J.
Έκδοση 2009

Synthesis and Antimicrobial Evaluation of Amixicile-Based Inhibitors of the Pyruvate-Ferredoxin Oxidoreductases of Anaerobic Bacteria and Epsilonproteobacteria

ανά Kennedy, Andrew J., Bruce, Alexandra M., Gineste, Catherine, Ballard, T. Eric, Olekhnovich, Igor N., Macdonald, Timothy L., Hoffman, Paul S.
Τόπος έκδοσης Antimicrob Agents Chemother (2016)

Synthesis and structure–activity relationships of tyrosine-based inhibitors of autotaxin (ATX)

ανά East, James E., Kennedy, Andrew J., Tomsig, Jose L., De Leon, Alexandra R., Lynch, Kevin R., Macdonald, Timothy L.
Έκδοση 2010

Synthesis and Antimicrobial Evaluation of Nitazoxanide-Based Analogues: Identification of Selective and Broad Spectrum Activity

ανά Ballard, T. Eric, Wang, Xia, Olekhnovich, Igor, Koerner, Taylor, Seymour, Craig, Salamoun, Joseph, Warthan, Michelle, Hoffman, Paul S., Macdonald, Timothy L.
Έκδοση 2010

Synthesis and biological evaluation of γ-aminophosphonates as potent, sub-type selective sphingosine 1-phosphate receptor agonists and antagonists

ανά Foss, Frank W., Snyder, Ashley H., Davis, Michael D., Rouse, Michael, Okusa, Mark D., Lynch, Kevin R., Macdonald, Timothy L.
Έκδοση 2006

Asymmetric Synthesis of Conformationally Constrained Fingolimod Analogues—Discovery of an Orally Active Sphingosine 1-Phosphate Receptor Type-1 Agonist and Receptor Type-3 Antagoni...

ανά Zhu, Ran, Snyder, Ashley H., Kharel, Yugesh, Schaffter, Lisa, Sun, Qin, Kennedy, Perry C., Lynch, Kevin R., Macdonald, Timothy L.
Έκδοση 2007

Synthesis and Biological Evaluation of Phosphonate Derivatives as Autotaxin (ATX) Inhibitors

ανά Cui, Peng, Tomsig, Jose L., McCalmont, William F., Lee, Sangderk, Becker, Christopher J., Lynch, Kevin R., Macdonald, Timothy L.
Έκδοση 2007

Development of a phosphatase-resistant, L-tyrosine derived LPA1/LPA3 dual antagonist

ανά East, James E., Carter, Karen M., Kennedy, Perry C., Schulte, Nancy A., Toews, Myron L., Lynch, Kevin R., Macdonald, Timothy L.
Έκδοση 2011

Synthesis and Biological Evaluation of Sphingosine Kinase Substrates as Sphingosine-1-Phosphate Receptor Prodrugs

ανά Foss, Frank W., Mathews, Thomas P., Kharel, Yugesh, Kennedy, Perry C., Snyder, Ashley H., Davis, Michael D., Lynch, Kevin R., Macdonald, Timothy L.
Έκδοση 2009

Characterization of a Sphingosine 1-Phosphate Receptor Antagonist Prodrug

ανά Kennedy, Perry C., Zhu, Ran, Huang, Tao, Tomsig, Jose L., Mathews, Thomas P., David, Marion, Peyruchaud, Olivier, Macdonald, Timothy L., Lynch, Kevin R.
Έκδοση 2011

SPHINGOSINE KINASE TYPE 1 INHIBITION REVEALS RAPID TURNOVER OF CIRCULATING SPHINGOSINE 1-PHOSPHATE

ανά Kharel, Yugesh, Mathews, Thomas P., Gellett, Amanda M., Tomsig, Jose L., Kennedy, Perry C., Moyer, Morgan L., Macdonald, Timothy L., Lynch, Kevin R.
Έκδοση 2011