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Synthesis and structure–activity relationships of tyrosine-based inhibitors of autotaxin (ATX)
Autotaxin (ATX) is a secreted soluble enzyme that generates lysophosphatidic acid (LPA) through its lysophospholipase D activity. Because of LPA’s role in neoplastic diseases, ATX is an attractive therapeutic target due to its involvement in LPA biosynthesis. Here we describe the SAR of ATX inhibito...
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| Asıl Yazarlar: | , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2010
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2975792/ https://ncbi.nlm.nih.gov/pubmed/20951039 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.09.030 |
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