Wird geladen...

Synthesis and structure–activity relationships of tyrosine-based inhibitors of autotaxin (ATX)

Autotaxin (ATX) is a secreted soluble enzyme that generates lysophosphatidic acid (LPA) through its lysophospholipase D activity. Because of LPA’s role in neoplastic diseases, ATX is an attractive therapeutic target due to its involvement in LPA biosynthesis. Here we describe the SAR of ATX inhibito...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: East, James E., Kennedy, Andrew J., Tomsig, Jose L., De Leon, Alexandra R., Lynch, Kevin R., Macdonald, Timothy L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975792/
https://ncbi.nlm.nih.gov/pubmed/20951039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.09.030
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!