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Synthesis and structure–activity relationships of tyrosine-based inhibitors of autotaxin (ATX)

Autotaxin (ATX) is a secreted soluble enzyme that generates lysophosphatidic acid (LPA) through its lysophospholipase D activity. Because of LPA’s role in neoplastic diseases, ATX is an attractive therapeutic target due to its involvement in LPA biosynthesis. Here we describe the SAR of ATX inhibito...

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Detaylı Bibliyografya
Asıl Yazarlar: East, James E., Kennedy, Andrew J., Tomsig, Jose L., De Leon, Alexandra R., Lynch, Kevin R., Macdonald, Timothy L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2010
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2975792/
https://ncbi.nlm.nih.gov/pubmed/20951039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.09.030
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