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Synthesis and Biological Evaluation of Phosphonate Derivatives as Autotaxin (ATX) Inhibitors
Autotaxin (ATX) is an autocrine motility factor that promotes cancer cell invasion, cell migration and angiogenesis. ATX, originally discovered as a nucleotide phosphodiesterase, is known now to be responsible for the lysophospholipid-preferring phospholipase D activity in plasma. As such, it cataly...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4116752/ https://ncbi.nlm.nih.gov/pubmed/17257836 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2006.12.114 |
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